Pagoclone- promising?

Maguire G, Franklin D, Vatakis NG, Morgenshtern E, Denko T, Yaruss JS, Spotts C, Davis L, Davis A, Fox P, Soni P, Blomgren M, Silverman A, Riley G.

University of California, Irvine School of Medicine, Orange, CA 92868, USA. gerald.maguire@uci.edu

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My Experience with Medications

I realize that there are a couple of threads about medications but thought I'd create a new post as over the last 12 months or so I have had the chance to 'experiment' with some prescription drugs which have been known to aid stutterers. These have been my experiences:

First of all, Im very lucky to have a doctor who is willing and interested in helping stutterers through pharmacology. I meet with him once a month and he monitors me very closely to ensure that I am not abusing or reacting badly to any of the meds. I am a 32 year old male, healthy (touch wood) and have no known allergies to any medications.

Secondly, I realize that everyone is different and some people react differently to any medication. Therefore, any side effects I have noted below should not be taken for granted that you will have similar experience. The same can be said for any resulting fluency.

Inderal/proprananol:
Propranolol (INN) is a non-selective beta blocker mainly used in the treatment of hypertension. Although it is commonly used to treat high blood pressure, it is also used to treat stage fright and public speaking.

I usually take 40mg of inderal per day. I have not noticed a huge increase in fluency when using inderal on its own. I have found it quite useful in combination with other meds however. I have noticed no side effects whatsoever from using inderal. I just make sure to check my heart rate so that it is not below normal.

Zyprexa:
Olanzapine (trade names Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera or in combination with fluoxetine Symbyax) is an atypical antipsychotic, approved by the FDA for the treatment of schizophrenia and bipolar disorder.
I have used zyprexa (5mg) per day. However, I have taken it only as needed so cannot comment on common side effects such as weight gain etc. I found that using zyprexa improves my fluency 50% to 70%. For example, I would use Zyprexa by taking a 5mg tablet (in combination with 40mg inderal) about 2 hours before evening classes at college where I have to speak alot and do presentations.

The zyprexa gave me a feeling of apathy. It felt as though I didnt really care if I blocked or not, this increased my fluency, however I suffered bad side effects. I would feel too apathetic and that bothered me. It also made me very, very tired. I tried to use energy supplements like vitamin B12 and energy drinks however, this didnt help and I usually needed to sleep a couple of hours during the day.

It must be said that I also used DAF (Delayed Auditory Feedback) app on my iphone sometimes in conjunction with using zyprexa. I use this by plugging headphones with an integrated mic into my iphone. This helped my fluency alot and the combination of both medication and DAF was a great help.

The side effects were too strong for me however and I stopped using Zyprexa. I just couldnt handle the tired feeling it gave me.

Abilify
Aripiprazole (pronounced /ˌɛərɨˈpɪprəzoʊl/ AIR-i-PIP-rə-zohl; brand names: Abilify, Aripiprex) is an atypical antipsychotic and antidepressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression.
Due to the negative side effects of Zyprexa, my doctor suggested that I try Abilify which he said alot of people use when they do not like the sides associated with zyprexa.
I tried 2mg to 4mg per day. Simply put, I tried it once, hated it and never tried it again. If anything I found it made my stammering worse. It seemed to make me agitated and not at all calm. Perhaps it just didnt agree with me but certainly did not increase fluency.

Xanax
Alprazolam (trade name Xanax, among others) is a potent short-acting drug of the benzodiazepine class. It is primarily used to treat moderate to severe anxiety disorders (e.g., social anxiety disorder) and panic attacks, and is used as an adjunctive treatment for anxiety associated with moderate depression.
My doctor was reluctant to try Xanax. It is very addictive and can be abused easily. However, he trusted me and started me on 0.5mg x2 twice per day but taken only as needed. I did not take it everyday. I used it by taking a couple of .5mg tablets about an hour before giving presentations in college. Again, I took this in combination with 40mg of inderal with the recommendation of my doctor.
Xanax works very fast and gives you a feeling which I could best describe as freeing your inhibitions, similar to alcohol. Alcolhol usually increases my fluency and so did xanax. My fluency increased 50% to 70% and was great for doing presentations. However, I found it wore off quite quickly. It has a half life of about 6 hrs. My only negative side effect was that I had short term memory loss. The next day I would try to recall my presentation or small details of the class and found it quite difficult to remember. I also slept very well after taking xanax and did not feel the 'come down agitation' that my doctor warned me about.

I also used xanax in combination with DAF technology and found it increased my fluency moreso.

Ativan
Lorazepam (initially marketed under the brand names Ativan and Temesta) is a high-potency short-to-intermediate-acting 3-hydroxy benzodiazepine drug that has all five intrinsic benzodiazepine effects: anxiolytic, amnesic, sedative/hypnotic, anticonvulsant and muscle relaxant.[4][5] Lorazepam is used for the short-term treatment of anxiety, insomnia, acute seizures including status epilepticus and sedation of hospitalised patients, as well as sedation of aggressive patients.[5][6][7][8]

Recently, My doctor suggested I try ativan which is similar to xanax but has a longer half life of about 12 hours. I take 2mg (2x1mg tablets) and I also use it in combination with 40mg of inderal. I find the same level of fluency as I did with xanax. It is not as strong as xanax but definitely has the same effect. I dont have the same level of short term memory loss as xanax. For example I went into the city at the weekend and did some 'contacts' with another McGuire program grad. My speech was absolutely fluent with little or no blocks.

It must be said that I usually am quite fluent when doing contacts (stopping people in the street, asking questions) when Im with another McGuire grad. Im not so fluent when Im on my own but thats a whole different story

Anyway, on Saturday I was 'near perfect' fluency when using the ativan in combination with my McGuire Program breathing technique. I have also found that using DAF technology with ativan is very beneficial. I had an interview last week in college for a job and my speech fluency was increased about 70%. I think if I could somehow discipline myself to use breathing techniques in combination with ativan it would be a great combination for me.

In conclusion, I find the 2 x 1mg of ativan works best in combination with 2 x 20mg of inderal. This in combination with DAF technology works very well and again, using a diaphragm breathing technique increases fluency even more.

I am continuing to use Ativan and I am VERY careful only to take it 'as needed'. This means I might use it only 3 days in a week. In this way I do not become dependent on it which can be a problem with these types of medication.

If you are interested in trying medications to treat your stammer, I hope my post helps in some way. I cannot emphasize how important it is to have the support and guidance of your doctor. Let me know if you have any questions or comments...

My Experience with Medications

I realize that there are a couple of threads about medications but thought I'd create a new post as over the last 12 months or so I have had the chance to 'experiment' with some prescription drugs which have been known to aid stutterers. These have been my experiences:

First of all, Im very lucky to have a doctor who is willing and interested in helping stutterers through pharmacology. I meet with him once a month and he monitors me very closely to ensure that I am not abusing or reacting badly to any of the meds. I am a 32 year old male, healthy (touch wood) and have no known allergies to any medications.

Secondly, I realize that everyone is different and some people react differently to any medication. Therefore, any side effects I have noted below should not be taken for granted that you will have similar experience. The same can be said for any resulting fluency.

Inderal/proprananol:
Propranolol (INN) is a non-selective beta blocker mainly used in the treatment of hypertension. Although it is commonly used to treat high blood pressure, it is also used to treat stage fright and public speaking.

I usually take 40mg of inderal per day. I have not noticed a huge increase in fluency when using inderal on its own. I have found it quite useful in combination with other meds however. I have noticed no side effects whatsoever from using inderal. I just make sure to check my heart rate so that it is not below normal.

Zyprexa:
Olanzapine (trade names Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera or in combination with fluoxetine Symbyax) is an atypical antipsychotic, approved by the FDA for the treatment of schizophrenia and bipolar disorder.
I have used zyprexa (5mg) per day. However, I have taken it only as needed so cannot comment on common side effects such as weight gain etc. I found that using zyprexa improves my fluency 50% to 70%. For example, I would use Zyprexa by taking a 5mg tablet (in combination with 40mg inderal) about 2 hours before evening classes at college where I have to speak alot and do presentations.

The zyprexa gave me a feeling of apathy. It felt as though I didnt really care if I blocked or not, this increased my fluency, however I suffered bad side effects. I would feel too apathetic and that bothered me. It also made me very, very tired. I tried to use energy supplements like vitamin B12 and energy drinks however, this didnt help and I usually needed to sleep a couple of hours during the day.

It must be said that I also used DAF (Delayed Auditory Feedback) app on my iphone sometimes in conjunction with using zyprexa. I use this by plugging headphones with an integrated mic into my iphone. This helped my fluency alot and the combination of both medication and DAF was a great help.

The side effects were too strong for me however and I stopped using Zyprexa. I just couldnt handle the tired feeling it gave me.

Abilify
Aripiprazole (pronounced /ˌɛərɨˈpɪprəzoʊl/ AIR-i-PIP-rə-zohl; brand names: Abilify, Aripiprex) is an atypical antipsychotic and antidepressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression.
Due to the negative side effects of Zyprexa, my doctor suggested that I try Abilify which he said alot of people use when they do not like the sides associated with zyprexa.
I tried 2mg to 4mg per day. Simply put, I tried it once, hated it and never tried it again. If anything I found it made my stammering worse. It seemed to make me agitated and not at all calm. Perhaps it just didnt agree with me but certainly did not increase fluency.

Xanax
Alprazolam (trade name Xanax, among others) is a potent short-acting drug of the benzodiazepine class. It is primarily used to treat moderate to severe anxiety disorders (e.g., social anxiety disorder) and panic attacks, and is used as an adjunctive treatment for anxiety associated with moderate depression.
My doctor was reluctant to try Xanax. It is very addictive and can be abused easily. However, he trusted me and started me on 0.5mg x2 twice per day but taken only as needed. I did not take it everyday. I used it by taking a couple of .5mg tablets about an hour before giving presentations in college. Again, I took this in combination with 40mg of inderal with the recommendation of my doctor.
Xanax works very fast and gives you a feeling which I could best describe as freeing your inhibitions, similar to alcohol. Alcolhol usually increases my fluency and so did xanax. My fluency increased 50% to 70% and was great for doing presentations. However, I found it wore off quite quickly. It has a half life of about 6 hrs. My only negative side effect was that I had short term memory loss. The next day I would try to recall my presentation or small details of the class and found it quite difficult to remember. I also slept very well after taking xanax and did not feel the 'come down agitation' that my doctor warned me about.

I also used xanax in combination with DAF technology and found it increased my fluency moreso.

Ativan
Lorazepam (initially marketed under the brand names Ativan and Temesta) is a high-potency short-to-intermediate-acting 3-hydroxy benzodiazepine drug that has all five intrinsic benzodiazepine effects: anxiolytic, amnesic, sedative/hypnotic, anticonvulsant and muscle relaxant.[4][5] Lorazepam is used for the short-term treatment of anxiety, insomnia, acute seizures including status epilepticus and sedation of hospitalised patients, as well as sedation of aggressive patients.[5][6][7][8]

Recently, My doctor suggested I try ativan which is similar to xanax but has a longer half life of about 12 hours. I take 2mg (2x1mg tablets) and I also use it in combination with 40mg of inderal. I find the same level of fluency as I did with xanax. It is not as strong as xanax but definitely has the same effect. I dont have the same level of short term memory loss as xanax. For example I went into the city at the weekend and did some 'contacts' with another McGuire program grad. My speech was absolutely fluent with little or no blocks.

It must be said that I usually am quite fluent when doing contacts (stopping people in the street, asking questions) when Im with another McGuire grad. Im not so fluent when Im on my own but thats a whole different story

Anyway, on Saturday I was 'near perfect' fluency when using the ativan in combination with my McGuire Program breathing technique. I have also found that using DAF technology with ativan is very beneficial. I had an interview last week in college for a job and my speech fluency was increased about 70%. I think if I could somehow discipline myself to use breathing techniques in combination with ativan it would be a great combination for me.

In conclusion, I find the 2 x 1mg of ativan works best in combination with 2 x 20mg of inderal. This in combination with DAF technology works very well and again, using a diaphragm breathing technique increases fluency even more.

I am continuing to use Ativan and I am VERY careful only to take it 'as needed'. This means I might use it only 3 days in a week. In this way I do not become dependent on it which can be a problem with these types of medication.